候选基因研究与创业基因的探寻

Candidate gene studies and the quest for the entrepreneurial gene

SMALL BUSINESS ECONOMICS · 2011
被引 21
人大 A-ABS 3

中文导读

指出候选基因研究在经济学和创业研究中日益流行,但以DRD3基因与创业倾向的关联为例,未能用更大数据集复制原发现,并讨论了如何避免假阳性结果。

Abstract

Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of the results. As an example, Nicolaou et al. (Small Bus Econ 36:151–155, 2011) report a significant association between a common genetic variant in the DRD3 gene and the tendency to be an entrepreneur. We fail to replicate this finding using a much larger, independent dataset. In addition, we discuss the candidate gene approach and give suggestions to avoid the publication of false positives.

创业研究行为遗传学经济学基因关联研究