Costs, effects and C/E‐ratios alongside a clinical trial
讨论了如何评估基于随机临床试验数据估算的成本效果比的不确定性，包括计算95%概率椭圆和引入成本效果可接受曲线，并用治疗脓毒症综合征的实例说明。
A general approach is discussed to assess the uncertainty surrounding the cost effectiveness ratio (C/E-ratio) estimated on the basis of data from a randomised clinical trial. The approach includes the calculation of a 95% probability ellipse and introduces the concept of a so called C/E-acceptability curve. This last curve defines for each predefined C/E-ratio the probability that the C/E-ratio found in the study is acceptable. The approach is illustrated by estimates of costs per life saved and costs per patient discharged alive on the basis of data from a phase II trial addressing the value of anakinra in treating sepsis syndrome.