Economic evaluation alongsiden-of-1 trials: getting closer to the margin
探讨在n-of-1试验中收集经济数据的独特优势，通过假设案例说明如何利用这类试验估计个体化的成本效果，对关注个体化医疗经济评估的研究者有用。
The n-of-1 trial is a particularly flexible form of randomized controlled trial that involves a single patient receiving multiple episodes of alternative therapies. Although n-of-1 trials are only applicable in certain treatment areas, the collection of economic data within such trials may provide unique advantages. This paper illustrates the issues around the use of economic n-of-1 trials with a hypothetical example, and discusses their potential for the estimation of individualized cost-effectiveness.