Impact of shift work on cardiovascular functions in a 10-year follow-up study
本研究追踪158名轮班工人和75名日班工人10年，发现轮班工作与心电图QTc间期延长相关，可能解释轮班工作增加心血管疾病风险的原因。
OBJECTIVES: The purpose of this study was to determine whether shift work affects the heart-rate-adjusted QT interval (QTc) in electorcardiography (ECG) and the blood pressure of workers without overt cardiovascular dysfunction. METHODS: At a copper smelter, 158 shift workers and 75 day workers who underwent an ECG examination and blood pressure measurements in 1986 were followed for 10 years. In 1996, biochemical indicators such as high-density lipoprotein cholesterol and triglycerides were measured, together with the QTc. RESULTS: In 1986 and 1996, the QTc was significantly longer in the shift workers than in the day workers. Of 180 workers with a normal QTc (<420 ms(1/2) in 1986, 15% had developed a prolonged QTc (420 ms(1/2) in 1996 (18% of the 117 shift workers and 11% of the 63 day workers). Among the workers with a normal QTc in 1986, the shift workers had a significantly longer QTc than the day workers when the QTc was examined in 1996. In addition, shift-day work in the group with a normal QTc was significantly related to the QTc in 1996 after control for age, work duration, biochemical indicators, smoking, and drinking habits. However, the blood pressures of the shift and day workers did not differ significantly, and in 1996 the values of both groups were significantly elevated. CONCLUSIONS: These data suggest that shift work is associated with QTc prolongation. This evidence may explain the increased risk for cardiovascular diseases due to shift work.