0333 The contribution of occupational studies to the identification of carcinogens in the IARC Monographs and how to further improve it
本文讨论了职业研究在识别致癌物中的关键作用，指出其贡献可进一步通过改进研究设计、方法和报告来提升，对职业健康和环境健康研究者有参考价值。
<h3>Objectives</h3> To discuss the important role of occupational studies in identifying carcinogens and suggest how it could be still greater. <h3>Method</h3> The contribution of occupational studies to the IARC monographs is reviewed. <h3>Results</h3> Occupational epidemiology has made important contributions beyond developing knowledge to protect workers’ health, notably in identifying carcinogens of concern for the general population. The IARC Monographs have evaluated many carcinogens for which occupational studies have provided key evidence. The recent classifications of diesel engine exhaust, trichloroethylene and polychlorinated biphenyls (PCBs) as human carcinogens, which depended heavily on data from occupational studies, are illustrative. In the evaluation of PCBs, for example, occupational cohort studies showing an exposure-related increase in the risk of malignant melanoma were pivotal for the conclusion of sufficient evidence of carcinogenicity. Despite such noteworthy contributions, the number of occupational studies that are ultimately informative tends to be relatively small relative to the number reviewed. The most informative studies tend to have common features, including clear reporting of methods and results, well-defined outcomes, quantitative estimates of exposure, adequate control of major confounders, and state of the art analytical methods, often with internal analyses of exposure-response. In contrast, studies that are too broadly focused and those with crude classifications of exposure or outcome, analyses by external comparisons alone or poor reporting of the methods and results are often less informative in the final evaluation. <h3>Conclusions</h3> While occupational studies are important for carcinogen identification, their relevance could be further enhanced with improvements in study design, methods and reporting.