17 Lead, blood pressure: a case-control study
研究比较了265名铅暴露工人与265名非暴露者的血压，发现暴露组血压显著升高，且血压随血铅水平上升而增加。
<h3></h3> In this study, we investigated the relationship between lead and blood pressure of 265 persons (aged 21–59 years) occupationally exposed to inorganic lead (PbB between 12.50 and 82.90 mg/dl) and 265 people (aged 23 to 59 years) who have ever been exposed to lead (blood lead levels between 0.5 and 5 mg/dl). At the time of hiring none of these people had high blood pressure or kidney disease or diabetes. The seniority of these workers varies from 1 year to 35 years. Apart from the basic blood pressure (Bp1: measured at the time of hiring) Blood pressure (Bp2) considered in this study or related to the first measurement of arterial hypertension or to the blood pressure measured in 2010 if the subject is normotensive. The results show that the difference in blood pressure between the 2 groups at the time of hiring (Bp1) is not statistically significant. By cons for the Bp2 there is a statistically significant difference between the two groups. The study of the survival curves also show a significant difference between the two groups in terms of systolic pressure diastolic. In the exposed cohort, a multivariate analysis taking into account the covariates and interrelation between the variables shows a an increase in systolic blood pressure and diastolic according of blood lead levels. In Conclusion Results show that in this study there is a relationship between increased blood pressure and increased levels of blood lead.