Percutaneous absorption of 2-butoxyethanol in man.
研究了5名男性志愿者手指浸泡在2-丁氧基乙醇中2小时后的经皮吸收情况，通过血液和尿液检测确认该物质能进入人体循环，吸收速率范围为7-96 nmol/min/cm²，提示大面积皮肤接触有急性中毒风险。
The percutaneous absorption of the commonly used glycol ether 2-butoxyethanol (ethylene glycol monobutyl ether) was investigated in 12 exposure experiments with five men. The subject kept two or four fingers immersed in neat butoxyethanol for 2 h. Arterialized capillary blood samples were collected from the other hand before, during, and up to 4 h after the exposure and analyzed for butoxyethanol by gas chromatography. Urine was collected for 24 h and analyzed for the metabolite butoxyacetic acid, also by gas chromatography. The presence of butoxyethanol in blood and of butoxyacetic acid in urine confirmed that butoxyethanol enters the systemic circulation in man in vivo during dermal exposure. Percutaneous uptake rates were calculated from measured blood levels of butoxyethanol with the use of kinetic parameters (clearance and volume of distribution) obtained in earlier experiments with the same subjects. The uptake rates ranged from 7 to 96 nmol.min-1.cm-2. The results indicate that persons exposing large portions of their skin to butoxyethanol are at risk of absorbing acutely toxic doses.