391 Association between occupational exposure to wood dust and risk of nasopharyngeal cancer: A case-control study from Thailand
在泰国开展的一项病例对照研究发现，职业性木尘暴露与鼻咽癌风险增加有关，尤其对于有明确暴露史、中等暴露频率和低暴露强度的人群。
<h3>Objectives</h3> To explore possible association between occupational wood dust exposure and risk of nasopharyngeal cancer (NPC), a matched case - control study was conducted in Bangkok and 6 regional cancer treatment centers in Thailand. <h3>Methods</h3> Three hundred and twenty-seven diagnosed NPC cases were compared with 327 age and gender matched controls. Data of socio-demographic characteristics and potential risk factors were collected by personal interviews. Wood dust exposures were assessed by 3 industrial hygienists by reading lifetime occupational histories of the participants with unknown for case-control status. Assessments were done for probability, frequency and intensity of exposure to wood dust. Multivariate analyses were performed adjusting for educational level, smoking status and histories of chronic sinusitis. <h3>Results</h3> We found the association between occupational wood dust exposure and NPC risk (OR 1.66, 95% CI 1.03 - 2.67) especially for those who have definite probability of exposure (OR 1.77, 95% CI 1.04 - 3.00), moderate frequency of exposure (OR 2.8, 95% CI 1.22 - 6.39) and low intensity of exposure (OR 2.29, 95% CI 1.15 - 4.59). <h3>Conclusion</h3> Results of this study shows that occupational exposure to wood dust are likely to be associated with increasing risk of NPC.