Inhibition of synaptosome membrane-bound integral enzymes by organic solvents.
以突触体膜为模型，研究有机溶剂对膜结合整合酶活性的影响，发现芳香烃和氯化脂肪烃浓度依赖性地抑制乙酰胆碱酯酶和ATP酶，而醇类无显著作用，提示有机溶剂的中枢抑制效应可能与膜整合蛋白相互作用有关。
The possible mechanism of the depressive effect of organic solvents on the central nervous system (CNS) was studied with synaptosome membranes as a model. The changes in the activities of the membrane-bound integral enzymes acetylcholinesterase, total adenosinetriphosphatase, and magnesium-activated adenosinetriphosphatase were determined after treatment with different concentrations of organic solvents in vitro. Aromatic hydrocarbons and chlorinated aliphatic hydrocarbons inhibited all the enzyme activities concentration dependently. Alcohols had no significant effect at the same dose levels. The results of the present study suggest that the CNS depressive effect of organic solvents may be based on their interaction with membrane integral proteins.