0195 Carbon nanotube exposure assessment for a study on early biological effects; the CANTES study
该研究评估了碳纳米管生产工厂中生产、研发和办公室三类工人的个人暴露水平，发现生产工人几何平均暴露量为42.6 μg/m³，研发工人为4.6 μg/m³，为后续健康效应研究提供暴露数据。
<h3>Objectives</h3> To assess personal exposure to carbon nanotubes for a study of early effect biomarkers among workers exposed to carbon nanotubes (CNTs). <h3>Method</h3> Three major job categories were identified in the exposed factory: production, R&D and office. For qualitative assessment personal 8-hr-TWA inhalable dust samples (n = 5) were collected in all job categories and analysed by SEM-EDX. For quantitative assessment 8-hr TWA samples (n = 30) were collected from the production and R&D workers and analysed for elemental carbon, corrected for soot using SEM/EDX. Job activities were recorded during all measurements. <h3>Results</h3> The qualitative analyses demonstrated the presence of CNTs in the personal breathing zone of production, R&D and office workers. CNT agglomerates with particle sizes between 500 nm and 100 μm were identified for production and R&D workers and between 500 nm and 5 μm for office workers. No single CNTs were identified. The quantitative analyses demonstrated geometric mean (GM) inhalable CNT levels of 42.6 μg/m<sup>3</sup> (min-max: 1.4–1186.5) and 4.6 μg/m<sup>3</sup> (min-max: 0.2–59.5) for the production and R&D workers, respectively. <h3>Conclusions</h3> We identified exposure to clusters of CNT in production, R&D and office workers of the CNT production facility. As expected GM exposure was higher for production than for R&D workers, however considerable variability was observed. Additional quantitative measurements in office and production workers are ongoing. For the full set, analyses of within- and between-worker variability and activity as a determinant will be performed. This information will be used to assess personal exposure in a cross-sectional study of early health effects in the CANTES study.