Time to pregnancy study in male workers exposed to carbon disulfide in the rayon industry
研究人造丝行业男性工人接触二硫化碳对夫妻生育能力的影响，发现长期高浓度接触会显著降低生育能力。
<h3>Objectives</h3> The aim of study was to investigate whether exposure to carbon disulfide (CS<sub>2</sub>) has an impact on couple fecundability. <h3>Methods</h3> A total of 56 male workers in the rayon industry were recruited in this retrospective cohort study. We used time to pregnancy (TTP) as a measure of couple fecundability, which was defined as the duration between the dates of discontinuing contraceptive procedures and beginning of last menstrual period before pregnancy, and used a structured questionnaire to interview each male worker and his spouse. We conducted the exposure assessment of CS<sub>2</sub> using previously air-sampling data. Finally, we analysed the data of TTP using the discrete Cox9s proportional hazards model. <h3>Results</h3> The pregnancies with the employment of 10 years or more had a lower fecundability density ratio (FDR=0.47; 95% CI: 0.23 to 0.93) and those exposed more than 30 ppm had a lower ratio (FDR=0.58; 95% CI: 0.26 to 1.29) compared to those before the employment. Furthermore, workers exposed more than 30 ppm and their employment of 10 years or more were associated with a decreased fecundability density ratio (FDR=0.42; 95% CI: 0.19 to 0.93). <h3>Conclusions</h3> The results showed that the exposure to CS<sub>2</sub> had a significantly detrimental effect on male fecundability, especially for those with long duration and high level of CS<sub>2</sub> exposure.