0431 The contribution of molecular epidemiology to studying occupational disease: some accomplishments to date and opportunities for the future
本文总结了分子流行病学在职业病研究中的贡献，包括增强剂量反应关系研究、评估暴露与不良结局的生物学合理性，以及揭示暴露-疾病关系的机制，并指出这些研究补充了经典流行病学调查。
<h3>Objectives</h3> There are several contributions that molecular epidemiology can make to the study of occupational disease. <h3>Method</h3> These include 1) enhancing the ability to study dose-response relationships; 2) evaluating the biological plausibility that an exposure may be related to an adverse outcome; and 3) providing insight into the underlying biological mechanism of an established or suspected exposure-disease relationship. These goals can overlap at times. <h3>Results</h3> There are multiple examples where molecular epidemiology studies have contributed important information about occupational exposures, including instances where such studies contributed data that played a role in determining if a given exposure was causally related to disease. Historically, these studies have complimented classic epidemiological investigations. <h3>Conclusions</h3> There are multiple examples where molecular epidemiology studies have contributed important information about occupational exposures, including instances where such studies contributed data that played a role in determining if a given exposure was causally related to disease. Historically, these studies have complimented classic epidemiological investigations.