Pregnancy outcomes among female dental personnel – a registry-based retrospective cohort study
本研究基于挪威1967-2006年的登记数据，比较了女性牙科人员（牙医和牙科助理）与普通人群的妊娠结局，未发现先天性畸形或其他不良妊娠结局的风险增加。
OBJECTIVES: The aim of this study was to investigate whether women who have worked as dental personnel in Norway, a group with possible previous exposure to mercury vapor, have had an excess risk of having children with congenital malformations or other adverse pregnancy outcomes compared to the general population. METHODS: A cohort of female dental personnel was identified from the archives of the public dental healthcare and the national trade unions in Norway. Data on births and pregnancy outcomes during 1967-2006 were obtained from the Medical Birth Registry of Norway (MBRN). The final cohort of dental personnel consisted of 4482 dental assistants and 1011 dentists. All other women registered in the MBRN were assigned to the control group, in total 1,124,758. Excess risks of several adverse pregnancy outcomes for dental personnel compared to the general population were estimated. Analyses were conducted for the whole time period as well as stratified by 10-year periods. RESULTS: Female dental personnel had no observed increased occurrence of congenital malformations (including malformations of the central nervous system, dysplasia of the hip, clubfoot, malformations of the heart and great vessels), low birth weight, preterm birth, small for gestational age, changed gender ratio, multiple birth, stillbirth, or prenatal death. CONCLUSION: On a group level, we did not observe any excess risks of congenital malformations or other adverse pregnancy outcomes among female dental personnel in Norway during 1967-2006 compared to the general population.