Distribution and elimination of 14C-styrene in rat.
研究了雄性大鼠吸入放射性标记苯乙烯后，其在各器官组织中的分布与消除，发现皮下脂肪中含量最高，脑和肌肉浓度约为动脉血的70%。
Male rats were exposed to about 45 ppm of radioactively labeled styrene in the inspired air for 1--8 h. The distribution and elimination of styrene and its metabolites in different organs and tissues were studied. To get an idea of the ratio between unmetabolized and metabolized styrene in organs and tissues, a supplementary study was performed in which five male rats were exposed to about 250 ppm of radioactively labeled styrene. The largest amounts of styrene and its metabolites were found in the subcutaneous fat, and the concentration displayed a sharp rise during the first 4 h of exposure in comparison with the following 4 h. The concentration of styrene and its metabolites in the cerebrum, cerebellum and muscles paralleled the arterial blood concentration throughout the entire period of exposure and amounted to about 70% of the arterial blood value. In the supplementary study an accumulation of styrene metabolites in subcutaneous fat was disclosed; it ranged from 15 to 20% during exposure.