Trends and prospects in experimental neurotoxicology.
本文简要调查了工业化合物的神经毒性机制，包括缺氧/组织毒性、反应性代谢物介导机制及累积负担效应，并强调测试系统应纳入产前和新生儿暴露，以理解发育效应并指导流行病学研究。
A brief survey is given of the neurotoxic mechanisms of selected industrial compounds. They can be divided for practical purposes into hypoxic or histotoxic mechanisms, reactive metabolite-mediated mechanisms and effects related to the accumulated burden. It is clear that this classification is not necessarily valid for the developing nervous system. Therefore, it is suggested that complete test systems for neurotoxic effects should also include prenatal and neonatal exposure. This inclusion is even more important because a significant proportion of embryotoxic or teratogenic effects are related to deleterious changes in the nervous system. An understanding of these developmental effects should also help in the design of epidemiologic studies.