Pesticide exposure and screen-identified neuropsychiatric disease in British sheep farmers
研究调查了英国养羊农民中慢性低剂量农药暴露（尤其是有机磷）与筛查发现的帕金森病、神经病变等神经精神疾病的关联，发现处理农药浓缩液与帕金森病风险升高相关。
<h3>Objectives</h3> Chronic low dose pesticide exposure, especially to organophosphates (OPs) has been associated with ill-health particularly in sheep farmers but in the absence of overt acute toxicity the epidemiological evidence linking chronic ill-health to such exposures is weak. Our aim was to determine whether neuropsychiatric disease was associated with pesticide exposure in sheep farmers. <h3>Methods</h3> 18 958 British farmers from the 1970s were identified using contemporaneous records held by the National Farmers9 Union, Sheep and Cattle Associations and through Shepherd9s Guides. Each farmer was sent a health and occupational questionnaire. The prevalence of screen identified depression, dementia, Parkinsonism and neuropathy was determined using previously published algorithms. Associations between work activities, handling the pesticide concentrate, and screen identified ill-health were determined after adjustment for demographic variables. <h3>Results</h3> Screen-identified ill-health was associated with the somatic symptom severity score and ever seeking advice for pesticide poisoning. Handling the pesticide concentrate was associated with screen-identified Parkinsonism (OR<sub>adj</sub> 1.76, 95% CI 1.06 to 2.92) and to a lesser extent with neuropathy (OR<sub>adj</sub> 1.58, 95% CI 0.96 to 2.60) but not depression or dementia. After excluding those participants who had sought advice for pesticide poisoning, risks for Parkinsonism and neuropathy remained elevated but were no longer significant. After stratification by somatic symptom severity score, associations were found only in farmers with low scores. <h3>Conclusions</h3> Results are consistent with the a priori hypothesis linking chronic low dose exposure to ill-health but require confirmation using more precise measures of exposure and outcome. Somatisation does not appear to play an important role in this population.