Mortality in a population highly exposed to polychlorinated biphenyls and polychlorinated dibenzofurans: 30 years after Yucheng accident
研究1979年台湾油症事件中摄入多氯联苯/多氯二苯并呋喃的受害者30年后的死亡率，发现全因死亡率显著升高，男性肝癌、胃癌等风险增加，女性循环系统疾病风险上升。
Objectives In 1979, approximately 2000 victims in central Taiwan accidentally ingested rice oil contaminated with polychlorinated biphenyls/dibenzofurans (PCBs/PCDFs). In this study, we compared mortality between the exposed subjects and their neighbourhood referents 30 years after Yucheng accident. Methods We obtained age- and gender-matched referents from the 1979 neighbourhood of the exposed people. Cause-specific mortality (classified by ICD-9 codes) was compared between exposed subjects (N=1803) and their neighbourhood referents (N=5170). Age-modified indirect standardised mortality ratios (indirect-SMR) were calculated utilising the Yucheng subjects' neighbourhood referents as reference group. Total person-years of Yucheng subjects and neighbourhood referents were 48 751 and 141 774, respectively. Results All-cause mortality was significantly elevated in Yucheng subjects (SMR 1.2, 95% CI 1.1 to 1.3). Among Yucheng males, SMRs for chronic liver disease and cirrhosis (2.5, 1.5 to 3.9), stomach cancer (3.5, 1.5 to 7.0) and lymphatic and haematopoietic cancer (3.0, 1.1 to 6.6) were increased. Among Yucheng females, SMRs for disease of the circulatory system (1.5, 1.0 to 2.1) and systemic lupus erythematosus were increased (5 in Yucheng females, 0 in neighbourhood referents). Conclusions This is a long-term follow-up study comparing the mortality experience in people highly exposed to PCBs and PCDFs 30 years ago to that in a socio-economically comparable referent group. We found an increase in overall mortality, as well as other organ systems and some malignancies.