0088 Nervous System Disease among Korean Workers Exposed to Manganese
通过大规模队列研究发现，韩国锰暴露工人因神经系统疾病住院的风险显著高于普通男性，尤其是锥体外系和运动障碍疾病，提示锰暴露与神经系统损伤相关。
<h3>Objectives</h3> Exposure to excess levels of manganese in occupational settings has been associated with a neurological syndrome. So morbidity of nervous system disease among Korean workers exposed to manganese described through this large cohort study. <h3>Method</h3> Using medical surveillance data, hospital admission of nervous system disease (GOO-G99) from 2000 to 2005 was analysed in cohort contained manganese exposed male workers (438,693 person years). Also, 2% of Korean men was randomly selected and analysed their hospital admission data. Standardised Admission Ratios (SAR) of nervous disease among manganese exposed workers was estimated reference to Korean men. <h3>Results</h3> For 6 years, 500 admissions with nervous system diseases (G00-G99) were observed in solvents exposed workers. SARs for overall nervous diseases (G00-G09) (SAR=1.24, 95% CI 1.13–1.35), inflammatory disease of CNS (G00-G09) (SAR=1.92, 95% CI 1.52–2.39), other degenerative diseases of nervous system (G31) (SAR=3.60, 95% CI 1.16–8.40) and nerve, nerve root and plexus disorders (G50-G59) (SAR=1.66, 95% CI 1.36–2.00) were significantly higher than those of Korean men. SAR of extrapyramidal and movement disorders (G20-G26) was significantly high (SAR=2.03, 95% CI=1.05–3.55) among workers with 10 and more years employment duration. <h3>Conclusions</h3> This manganese exposed workers’ cohort with short follow-up periods exhibits significantly elevated admission with overall and some kinds of nervous disease comparing to Korean men. Especially, increased SAR of extrapyramidal and movement disorder suggests relatedness of manganese exposure.