Increased uptake of serotonin in platelets from car painters occupationally exposed to mixtures of solvents and organic isocyanates.
研究了12名暴露于溶剂和有机异氰酸酯混合物的汽车油漆工，发现其血小板血清素摄取率显著高于50名未暴露志愿者，提示该方法可用于早期检测有机溶剂和异氰酸酯暴露导致的器官损伤。
Twelve car painters occupationally exposed to mixtures of solvents and organic isocyanates were investigated concerning serotonin uptake in platelets. The data from the exposed workers were compared to data from a reference group consisting of 50 nonexposed volunteers. The mean platelet count in whole blood of the exposed workers was markedly lower than the corresponding value of the reference group. Three workers had values below the lower limit of the 95% tolerance interval of the referents. In both groups the serotonin transport strictly obeyed Michaelis-Menten's simple saturation kinetics. Nine of the twelve exposed workers had uptake rates which were significantly higher (p = 0.05) than those of the referents. The obtained data suggest that the present method may be used to reveal early organ damage, prior to the appearance of clinical symptoms, due to intermittent exposure to organic solvents and isocyanates.