Disappearance of carbon monoxide from the blood – comparison of the one-exponential and two-exponential elimination models for rat
研究比较了单指数和双指数模型拟合大鼠血液中一氧化碳消除的准确性，发现双指数模型统计上更优，但实际应用中单指数模型已足够可靠。
The elimination of carbon monoxide from rat blood was studied from a starting point of a nonsteady-state concentration of 40% for carboxyhemoglobin (COHb). The accuracy of the fit was statistically improved by the employment of a two-exponential elimination model rather than that of the one-exponential model. Yet, the differences in the COHb estimates attained with the two models were negligible. Therefore, for practical purposes, the one-exponential model seems reasonably reliable for estimating COHb.