A rapid method for the selective analysis of total urinary metabolites of inorganic arsenic.
提出一种快速、便捷的方法，用于常规测量尿液中无机砷及其代谢物（甲基砷酸和二甲基砷酸）的总量，避免海产品中有机砷的干扰，适用于职业暴露评估。
Total urinary arsenic has traditionally been used for assessing occupational exposure to inorganic arsenic. However, dietary arsenic, especially from seafood, may greatly influence this value. This paper describes a fast and convenient method for routinely measuring the combined amount of inorganic arsenic, methylarsonic acid, and dimethylarsinic acid, which are the major urinary metabolites after exposure to inorganic arsenic. Organic arsenic compounds of marine origin are not biotransformed to inorganic arsenic or methylated arsenic acids to any significance in the human body. They do not produce arsines when treated with the reducing agent in the proposed method and will therefore not interfere with the measurements. The sensitivity, accuracy, and precision of the proposed method are sufficient for the determination of concentrations of arsenic normally found in the urine of nonexposed persons. The method is based on a commercially available hydride generation kit attached to an atomic absorption spectrophotometer.