Exposure related mortality from obstructive lung diseases among workers in the Norwegian silicon carbide industry
研究挪威碳化硅行业工人因阻塞性肺病死亡的风险，发现碳化硅颗粒和方石英暴露与疾病相关，且不同工龄工人主要风险因素不同。
<h3>Objectives</h3> An excess mortality from asthma, chronic bronchitis, and emphysema, is previously reported from the silicon carbide (SiC) industry. Our objective was to study mortality from obstructive lung diseases (OLD) with relation to specific exposure factors, using a revised and extended job exposure matrix (JEM). <h3>Methods</h3> Cumulative exposures to quartz, cristobalite, SiC particles, and SiC fibres were assigned to a cohort of 1687 long-term SiC industry workers, using a detailed JEM. Standardised mortality ratios (SMRs) for underlying causes of death, 1951–2007, were calculated, and Poisson regression analyses of OLD as underlying or contributing cause of death were performed using categorised and log-transformed cumulative exposure variables. <h3>Results</h3> The SMR of OLD was increased at the highest level of cumulative exposure to all investigated exposure factors. In the internal analyses of OLD as underlying or contributing cause of death, a twofold increased risk was observed at both medium and high level of cumulative exposure to SiC particles, with a significant trend. In a model with log-transformed cumulative exposure variables, SiC particles was the exposure factor with the most stable increased risk estimate when controlled for other exposure factors, among workers with less than 15 years of total employment duration. Cristobalite seemed to be the most important exposure factor among workers with more than 15 years total employment. <h3>Conclusions</h3> Exposure to SiC and crystalline silica may contribute to OLD development among SiC industry workers in different time windows, and possibly through different mechanisms.