Frequency of sister chromatid exchange and hematological effects in pesticide-exposed greenhouse sprayers
研究了温室喷雾工人接触多种农药后，姐妹染色单体交换频率和血液指标的变化，发现非吸烟工人中SCE频率升高，但血液学参数无显著差异。
OBJECTIVES: A cross-sectional study was conducted to investigate whether exposure to pesticides in greenhouses causes hemato- or genotoxic damage in sprayers. METHODS: The frequency of sister chromatid exchange (SCE) in cultured lymphocytes and the number of blood erythrocytes, leucocytes, and thrombocytes were studied among 134 greenhouse sprayers exposed to a complex mixture of almost 50 insecticides, fungicides, and growth regulators and among 157 referents. RESULTS: The hematological profiles did not differ between the exposed and unexposed groups. The SCE frequency was elevated in nonsmoking, but not in currently smoking sprayers when compared with the referents. There was a slight tendency towards an increased SCE frequency with decreasing degree of protection during pesticide applications. The frequency of pesticide applications, lifetime pesticide exposure, and in-season plasma-cholinesterase inhibition (as an estimate of current exposure to organophosphates and carbamates) did not influence the SCE frequency or any of the hematological parameters. CONCLUSIONS: The present results suggest a genotoxic effect from combined subtoxic occupational pesticide exposure, whereas no hematogenic effects could be observed at the current exposure level.