Discovering carcinogens in the occupational environment. Methods of data collection and analysis of a large case-referent monitoring system.
该研究通过多癌种、多因素的病例对照设计，收集3726例男性癌症患者的职业史和暴露信息，用分层分析和逻辑回归识别可能的职业致癌物，为职业健康研究提供方法参考。
A multi-cancer site, multi-factor, case-referent study was undertaken to generate hypotheses about possible occupational carcinogens. About 20 types of cancer were included. Incident cases among men aged 35-70 years and diagnosed in any of the major Montreal hospitals were eligible. Probing interviews were carried out for 3 726 eligible cases. The interview was designed to obtain detailed lifetime job histories and information on potential confounders. Each job history was reviewed by a team of chemists who translated it into a history of occupational exposures. These occupational exposures were then analyzed as potential risk factors in relation to the sites of cancer included. For each site of cancer analyzed, referents were selected from among the other sites in the study. The analysis was carried out in stages. First a Mantel-Haenszel analysis was undertaken of all cancer-substance associations, stratifying on a limited number of covariates, and, then, for those associations which were noteworthy in the initial analysis, a logistic regression analysis was made taking into account all potential confounders. This report describes the fieldwork and analytical methods.