Lymphoma risk among animal breeders
基于欧洲六国EPILYMPH病例对照研究，分析动物饲养接触与淋巴瘤风险的关系，发现家禽饲养可能降低特定亚型风险。
<h3>Objectives</h3> Occupational contact with breeding animals might be implicated in lymphoma aetiology. <h3>Methods</h3> In 1998–2003, 2337 incident lymphoma cases and 2434 controls participated in the EPILYMPH case-control study in six European countries. A detailed occupational history was collected in cases and controls, including species of breeding animals, their approximate number, and circumstances of contact. We conducted a preliminary analysis on ever exposed to contact with breeding animals, and we stratified the analysis by age at first exposure, whether before or after 12. The OR and its 95% CI was calculated with unconditional logistic regression for all lymphomas, and its major subtypes, adjusting by age, gender, and education. <h3>Results</h3> Lymphoma risk (all subtypes combined) did not increase among those exposed to contact with breeding animals (OR = 1.0, 95% CI 0.8 to 1.2). Risk of DLBCL was significantly lower among subjects employed in poultry farms (OR = 0.6, 95% CI 0.4 to 1.0). This inverse association was observed among subjects who started exposure before or at age 12 (OR = 0.5, 95% CI 0.2 to 1.1), but not later. <h3>Conclusions</h3> Early occupational contact with poultry might be associated with a decrease in risk of specific lymphoma subtypes.