94 Male hormonal profile to workers exposed to toluene in a packaging plant industrial in Mexico city
研究墨西哥城包装厂工人长期接触低浓度甲苯对男性激素（促卵泡激素、促黄体生成素、睾酮）的影响，发现甲苯暴露与促卵泡激素下降、睾酮上升相关，对职业健康评估有参考价值。
<h3></h3> It is not well established that long-term contact to low concentration of toluene produces changes in male hormonal profile (MHP). <h3>Objective</h3> To identify changes in the MHP, consisting of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone, in workers exposed to toluene in an industrial packaging plant in Mexico City. <h3>Material and Methods</h3> Cross-sectional study that included 42 workers, from which were formed two groups: with high (HET) and low (LET) exposure to toluene; serum FSH, LH, testosterone and acid hippuric in urine were measured in all subjects. <h3>Results</h3> Hippuric acid in subjects with LET: 2.53 ± 1.20 g/g creatinine, and with HET: 6.31 ± 3.83 g/g creatinine (p = 0.02). Seric FSH concentration: 5.12 ± 0.77 and 3.55 ± 0.3 mU/mL (p = 0.02) in LET and HET respectively; LH: 2.66 ± 0.45 and 2.77 ± 0.21 (p = 0.81), and testosterone: 3.91 ± 0.34 and 4.86 ± 0.23 ng/mL (p = 0.04). By regression analysis, the correlation coefficient of FSH with hippuric acid: -0,182 (p = 0.031), with coefficient of determination of 11%, the LH: -0,007 (p = 0.88) and 0.05% respectively, and testosterone: + 0209 (p = 0.0001) and 34%. <h3>Conclusions</h3> The effect of toluene is evident on FSH; LH also decreased but not overwhelming; testosterone seems to have opposite response, perhaps explained by different sensitivity of the male gonads to toluene exposure. These findings appear to be the initial changes in MHP of workers exposed to the solvent in question.