Renal function of workers with low-level cadmium exposure.
研究了27名低水平镉暴露工人的肾功能，发现尿镉超过50 nmol/l时，尿中β2-微球蛋白、视黄醇结合蛋白等指标显著升高，提示需降低现行生物暴露限值。
The influence of occupational exposure to cadmium on renal function was examined in 27 male cadmium workers from plants with second-degree usage of cadmium. The levels of cadmium in the blood and urine and various protein concentrations in the urine and serum were determined. The urinary levels of beta 2-microglobulin, retinol-binding protein, and N-acetyl-beta-D-glucosaminidase were statistically significantly increased in workers with urinary cadmium levels above 50 nmol/l. SDS-PAGE electrophoresis with silver staining is probably a sensitive indicator of the early effects of cadmium on protein excretion. The currently recommended biological exposure limits may have to be lowered.