0233 Long-term styrene exposure impairs colour vision in fibreglass reinforced plastics laminators
研究了玻璃纤维增强塑料层压工长期接触苯乙烯与色觉损伤的关系，发现累积工作时间越长，色觉损伤风险越高，对职业健康监测有参考价值。
<h3>Objectives</h3> Although styrene has been reported to cause colour vision impairment, the results were still inconclusive. Whether the impairment was related to short-term or long-term exposure was not known. The study aims to evaluate colour vision in high styrene exposed fibreglass-reinforced plastics (FRP) laminators. <h3>Method</h3> Fifty workers from two yacht factories participated, including 23 FRP laminators and 27 non-FRP workers. Pre-shift colour confusion index (CCI) was measured on the first workday of a week by using Lanthony Desaturated Panel D-15d. Concentrations of volatile organic compounds related to FRP laminating were collected by a stainless canister, and then analysed using a GC/MS. Cumulative working hours for FRP laminating was obtained from daily administrative records of the companies. Logistic regression was used to assess correlation between cumulative working hours (past 0.5, 2, and 8 years) of FRP laminating and pre-shift CCI, where work time and CCI were stratified by median and the model was adjusted for age and regular alcohol consumption. <h3>Results</h3> The mean styrene exposure during FRP laminating was 4.2 ppm. The median of cumulative working hours for FRP laminating in the past 0.5, 2 and 8 years was 2, 49, 248 h respectively. Higher cumulative working hours for FRP laminating was associated with poor CCI (past 0.5 yrs, odd ratio (OR)=3.1, p = 0.1; past 2 yrs, OR=4.8, p = 0.03; past 8 yrs, OR=6.5, p = 0.01). The effect of long-term exposure to styrene appeared to be stronger than short-term exposure. <h3>Conclusions</h3> Long-term exposure to styrene from FRP laminating was associated with colour vision impairment.