Symptom reporting amongst farmers using pesticides to treat sheep
研究了英国农民用有机磷或非有机磷农药处理羊后，一周内出现流感样症状的情况，发现症状报告增加与农药使用相关，但有机磷与非有机磷用户间无显著差异。
<h3>Objectives</h3> Farmers who treat their sheep for ectoparasites with organophosphate (OP) dips report a range of flu-like symptoms known as ‘dipper’s flu9. The nature and causes of ‘dipper’s flu9 are poorly understood. The aim of this study was to investigate whether OP exposure was associated with acute ill health. <h3>Methods</h3> Data on the daily incidence of general illness, tiredness, headaches, fever, muscle aches, runny nose, sore throat, coughing, nausea and eye irritation (symptom complexes) and sheep treatment practices during the week following sheep treatment was obtained by using a self-reported diary. Associations between work practices and the incidence of symptom complexes were investigated by distributed lag models. <h3>Results</h3> 352 UK sheep farmers completed the diary. The incidence of all symptom complexes was significantly higher on days 1 and 2 than on day 7 but there was little evidence of any differences in symptom reporting between OP and non-OP users. The number of sheep treated was not linked to the incidence of acute ill-health (whatever lag model was used) except that the number of sheep treated on day 4 was associated with an increased risk of reporting ≥2 symptom complexes in OP users only. <h3>Conclusions</h3> The increase in symptom reporting after the use of both non-OPs and OPs may reflect a common response to pesticides of different modes of action. However, the lack of any association with biologically important exposure lags suggests other treatment related factors may well be important.