Evaluation of heavy metal exposure in blood and urine of workers performing silver brazing
研究了40名银钎焊工人和31名对照者的血液和尿液重金属、肾脏标志物及氧化应激指标，发现暴露组镉和铜水平显著升高，肾脏标志物IAP也升高，提示低水平暴露仍有健康风险。
<h3>Objectives</h3> Silver brazing activities expose workers to metal fumes of which the health effects are not well studied yet. The aim of this study was to assess a number of biochemical parameters (heavy metals, renal markers, and oxidative stress markers) in workers performing brazing with silver alloys. <h3>Methods</h3> Blood (B) concentrations of Pb, Cd, Mn and urine (U) concentrations of Cd, Mn, Cu and Zn were determined in 40 refrigeration industry workers frequently brazing with silver alloys and 31 non-exposed control subjects. Renal markers (NAG, IAP, microalbumin, β2micro, RBP) and oxidative stress markers (d-ROM, AOPP, GPx, SOD, 8-OHdG) were measured as well. <h3>Results</h3> Significantly higher geometric mean levels (s.e.m.) of Cd-B (1.64 (1.11) vs 0.23 (1.17) µg/l), Cd-U (0.71 (1.24) vs 0.14 (1.16) µg/g creatinine) and Cu-U (5.55 (1.08) vs 4.55 (1.06) µg/g creatinine) were found in exposed workers than in control subjects. In addition, significantly increased levels of IAP were found among exposed workers. Also, higher levels (not statistically significant) of d-ROM, AOPP, SOD, and 8-OHdG were detected in exposed subjects than in control subjects. <h3>Conclusions</h3> The results suggest relatively low occupational exposure levels to heavy metals. Nevertheless, Cd-B, Cd-U and Cu-U were significantly higher in exposed subjects, as well as levels of IAP, a marker associated with Cd toxicity. In addition, elevated levels of oxidative stress markers were found among exposed workers, though not significantly higher than among non-exposed subjects.