失效时间结局的巢式病例对照研究中的变量选择

Variable selection for case-cohort studies with failure time outcome

Biometrika · 2016
被引 21
ABS 4

中文导读

研究了在巢式病例对照设计中,使用平滑剪切绝对偏差惩罚进行变量选择的方法,证明了估计量的一致性和渐近正态性,并通过模拟和实际数据给出了应用建议。

Abstract

Case-cohort designs are widely used in large cohort studies to reduce the cost associated with covariate measurement. In many such studies the number of covariates is very large, so an efficient variable selection method is necessary. In this paper, we study the properties of a variable selection procedure using the smoothly clipped absolute deviation penalty in a case-cohort design with a diverging number of parameters. We establish the consistency and asymptotic normality of the maximum penalized pseudo-partial-likelihood estimator, and show that the proposed variable selection method is consistent and has an asymptotic oracle property. Simulation studies compare the finite-sample performance of the procedure with tuning parameter selection methods based on the Akaike information criterion and the Bayesian information criterion. We make recommendations for use of the proposed procedures in case-cohort studies, and apply them to the Busselton Health Study.

计量经济学生物统计学变量选择生存分析