Stereological Analysis of Anisotropic Structures Using Directional Statistics
提出一种参数化方法，利用固定方向探针估计各向异性结构中长度和表面密度，并以骨骼肌毛细血管数据为例，展示了Dimroth-Watson轴向分布的最大似然估计过程。
SUMMARY Classical stereological methods are based on the assumption of isotropy, either of the structure under study or of the sectioning probe relative to the structure. Thus, with distribution-free stereology, anisotropic structures can be studied only via isotropic uniform random probes, which are often difficult to generate or inefficient in practice. Here we present a parametric approach to model the direction of a randomly chosen line or surface element, whereby length and surface densities can be estimated by probes at fixed and known directions. For the material studied, namely skeletal muscle capillaries, the Dimroth-Watson axial distribution provides a good fit. A maximum likelihood procedure for estimating simultaneously the concentration parameter of the Dimroth-Watson distribution and either the length or the surface density for the structure is described and illustrated with the capillary data. When a particular axial model is known to be satisfactory, a short-cut estimation method of practical value can be used.