The Minimax Risk for Two-Stage Procedures in Clinical Trials
研究了在比较两种医疗方案的临床试验中，如何分配患者以最小化最大风险，并发现基于截断序贯概率比检验的简单分配规则几乎同样有效。
SUMMARY The risk involved in a trial to compare two medical treatments is shared by patients who receive the inferior treatment during the experimental phase and those remaining after the experiment who might all receive the inferior treatment if the results are misleading. We consider the maximum of this risk with respect to the unknown probabilities of success and seek allocation rules that minimize this quantity, for a given total of patients. It needs extensive computations to find such minimax procedures, but there are simple and almost equally effective allocation rules based on a truncated sequential probability ratio test.