Occupational exposure to pesticides and other biocides and risk of thyroid cancer
基于康涅狄格州462例甲状腺癌病例和498例对照的数据，研究发现职业接触生物杀灭剂使甲状腺癌风险升高（OR=1.65），高累积暴露风险更高（OR=2.18），但职业接触杀虫剂未见显著关联。
OBJECTIVES: To assess the associations between occupational exposure to biocides and pesticides and risk of thyroid cancer. METHODS: Using data from a population-based case-control study involving 462 incident thyroid cancer cases and 498 controls in Connecticut collected in 2010-2011, we examined the association with occupational exposure to biocides and pesticides through a job-exposure matrix. We used unconditional logistic regression models to estimate OR and 95% CI, adjusting for potential confounders. RESULTS: Individuals who were occupationally ever exposed to biocides had an increased risk of thyroid cancer (OR=1.65, 95% CI 1.16 to 2.35), and the highest risk was observed for the high cumulative probability of exposure (OR=2.18, 95% CI 1.28 to 3.73). The observed associations were similar when we restricted to papillary thyroid cancer and well-differentiated thyroid cancer. Stronger associations were observed for thyroid microcarcinomas (tumour size ≤1 cm). No significant association was observed for occupational exposure to pesticides. CONCLUSIONS: Our study provides the first evidence linking occupational exposure to biocides and risk of thyroid cancer. The results warrant further investigation.