Dimensionality Reduction and Variable Selection in Multivariate Varying-Coefficient Models With a Large Number of Covariates
针对基因-环境交互研究中协变量多、数据有限的问题，提出一种结合主成分降维、样条逼近和稀疏惩罚的变系数模型方法，能一致识别相关变量并高效估计系数函数。
Motivated by the study of gene and environment interactions, we consider a multivariate response varying-coefficient model with a large number of covariates. The need of nonparametrically estimating a large number of coefficient functions given relatively limited data poses a big challenge for fitting such a model. To overcome the challenge, we develop a method that incorporates three ideas: (i) reduce the number of unknown functions to be estimated by using (noncentered) principal components; (ii) approximate the unknown functions by polynomial splines; (iii) apply sparsity-inducing penalization to select relevant covariates. The three ideas are integrated into a penalized least-square framework. Our asymptotic theory shows that the proposed method can consistently identify relevant covariates and can estimate the corresponding coefficient functions with the same convergence rate as when only the relevant variables are included in the model. We also develop a novel computational algorithm to solve the penalized least-square problem by combining proximal algorithms and optimization over Stiefel manifolds. Our method is illustrated using data from Framingham Heart Study. Supplementary materials for this article are available online.