Clinical trial supply chain design based on the Pareto-optimal trade-off between time and cost
提出一个多目标临床站点选择模型，在缩短临床试验时间和控制成本之间寻找帕累托最优的供应链配置，帮助决策者设计高效供应链。
Long duration and high cost are two key characteristics of clinical trials. Since the clinical trial duration is part of the limited patent life and determines the time to market, its reduction is of critical importance. Although the duration can be reduced through increasing the number of clinical sites in the supply chain, the total enrollment and operational costs are also increased. Hence, Pareto-optimal supply chain configurations are used to improve clinical trial efficiency. In this study, we propose a multi-objective clinical site selection model that considers the trade-off between time and cost of clinical trials. An efficiency curve representing the Pareto-optimal trade-off is provided for decision makers to design the supply chain. To identify all Pareto-optimal supply chain configurations efficiently, we develop an algorithm based on proposed propositions. The optimality cuts are derived to improve the solving efficiency of this problem.