Optimal design of fMRI experiments using circulant (almost-)orthogonal arrays
本文发展了一套理论，解释了循环设计的结构，并系统构建了高效的功能磁共振成像实验设计，提供了统计最优的两水平循环设计，可用于估计血流动力学响应函数及比较两个响应函数。
Functional magnetic resonance imaging (fMRI) is a pioneering technology for studying brain activity in response to mental stimuli. Although efficient designs on these fMRI experiments are important for rendering precise statistical inference on brain functions, they are not systematically constructed. Design with circulant property is crucial for estimating a hemodynamic response function (HRF) and discussing fMRI experimental optimality. In this paper, we develop a theory that not only successfully explains the structure of a circulant design, but also provides a method of constructing efficient fMRI designs systematically. We further provide a class of two-level circulant designs with good performance (statistically optimal), and they can be used to estimate the HRF of a stimulus type and study the comparison of two HRFs. Some efficient three- and four-levels circulant designs are also provided, and we proved the existence of a class of circulant orthogonal arrays.