Multidrug resistant Escherichia coli isolated from asymptomatic school going children in Kibera slum, Kenya
研究了肯尼亚贫民窟580名无症状学龄儿童粪便样本，发现17%携带大肠杆菌，其中6.5%含致病基因，21.2%的致病菌株多重耐药，且学校位置与感染率相关。
Pathogenic Escherichia coli are of different types, currently grouped into six groups depending on the virulence gene(s) they possess. This study isolated pathogenic E. coli from 580 stool samples obtained in the month of August, 2016. The samples were obtained from asymptomatic school going children in one of the biggest urban slums in Kenya. Ten primary schools were randomly sampled and 40 to 80 stool samples collected from each school depending on the school population. Both gender and age were considered when sampling. Data obtained was analysed using single factor ANOVA to test association between school location and levels of infection with pathogenic bacteria. A total of 244 (17%) samples had E. coli. Out of these, 38 (6.5%) were shown to have one or a combination of the pathogenic genes, namely: ipaH, virF, st2, daaE, eae, aafII, stx1, bfp, lt and stII and were thus classified into seven groups. Of the pathogenic isolates 35 (21.2%) were multidrug resistant. There was an association between school location and the prevalence of pathogenic bacteria. In conclusion, asymptomatic school going children in the slum were found to be infected with multidrug resistant pathogenic E. coli. Key words: Enteropathogenic, E. coli, multidrug resistance, school going children, asymptomatic.