Are Sex Differences in Human Brain Structure Associated With Sex Differences in Behavior?
研究利用两个大型脑成像数据集，发现大脑结构与行为的性别差异之间存在微弱关联，主要由脑大小驱动，且两者具有中等遗传性。
On average, men and women differ in brain structure and behavior, raising the possibility of a link between sex differences in brain and behavior. But women and men are also subject to different societal and cultural norms. We navigated this challenge by investigating variability of sex-differentiated brain structure within each sex. Using data from the Queensland Twin IMaging study ( n = 1,040) and Human Connectome Project ( n = 1,113), we obtained data-driven measures of individual differences along a male–female dimension for brain and behavior based on average sex differences in brain structure and behavior, respectively. We found a weak association between these brain and behavioral differences, driven by brain size. These brain and behavioral differences were moderately heritable. Our findings suggest that behavioral sex differences are, to some extent, related to sex differences in brain structure but that this is mainly driven by differences in brain size, and causality should be interpreted cautiously.