Stabilizing Large-Scale Probabilistic Boolean Networks by Pinning Control
提出一种牵制控制策略来稳定概率布尔网络，该策略基于网络结构而非状态转移矩阵，能处理大规模稀疏网络，并用哺乳动物细胞周期突变模型验证了有效性。
This article aims to stabilize probabilistic Boolean networks (PBNs) via a novel pinning control strategy. In a PBN, the state evolution of each gene switches among a collection of candidate Boolean functions with preassigned probability distributions, which govern the activation frequency of each Boolean function. Due to the existence of stochasticity, the mode-independent pinning controller might be disabled. Thus, both mode-independent and mode-dependent pinning controller are required here. Moreover, a criterion is derived to determine whether mode-independent controllers are applicable while the pinned nodes are given. It is worth pointing out that this pinning control is based on the <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$n\times n$ </tex-math></inline-formula> network structure rather than <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$2^{n} \times 2^{n}$ </tex-math></inline-formula> state transition matrix. Therefore, compared with the existing results, this pinning control strategy is more practicable and has the ability to handle large-scale networks, especially sparsely connected networks. To demonstrate the effectiveness of the designed control scheme, a PBN that describes the mammalian cell-cycle encountering a mutated phenotype is discussed as a simulation.