Proximal mediation analysis
针对观测数据中未测量混杂问题,提出利用代理变量识别自然直接和间接效应的三种近端识别方法,并开发了半参数推断框架,得到局部有效、多重稳健的估计量。
Summary A common concern when trying to draw causal inferences from observational data is that the measured covariates are insufficiently rich to account for all sources of confounding. In practice, many of the covariates may only be proxies of the latent confounding mechanism. Recent work has shown that in certain settings where the standard no-unmeasured-confounding assumption fails, proxy variables can be leveraged to identify causal effects. Results currently exist for the total causal effect of an intervention, but little consideration has been given to learning about the direct or indirect pathways of the effect through a mediator variable. In this work, we describe three separate proximal identification results for natural direct and indirect effects in the presence of unmeasured confounding. We then develop a semiparametric framework for inference on natural direct and indirect effects, which leads us to locally efficient, multiply robust estimators.