Efficiency Robust Score Tests for Rodent Tumourigenicity Experiments
针对啮齿动物致瘤实验中致命性和偶发性肿瘤的时间调整分析，提出一种效率稳健的得分检验，在多种情况下保持接近完全效率，而标准检验可能只有70%的效率。
The standard statistical test for assessing adverse effects in rodent tumourigenicity experiments is based on a time-adjusted analysis of lethal and incidental tumours. This test is shown to arise as the sum of two score statistics for fatal and incidental lesions respectively, the former optimal against extreme value hazard alternatives and the latter optimal against logistic prevalence alternatives in terms of asymptotic relative efficiency in the Pitman sense. An efficiency robust test is developed which retains near full efficiency in the extreme value/logistic situation as well as in other situations where the standard test may be only 70% efficient.