The Analysis of Multiple Correlated Binary Outcomes: Application to Rodent Teratology Experiments
本文针对发育毒性研究中胎儿缺陷数据的双重嵌套结构，改编了Liang和Zeger的方法，以恰当处理相关性，适用于毒理学家和统计学家。
Abstract In a developmental toxicity study, pregnant animals are exposed to the test substance and their offspring are assessed for defects. Often, multiple observations are made on each fetus, in which case the data are doubly nested. In this article we adapt the approach of Liang and Zeger (1986) and Zeger and Liang (1986) to yield an analysis, which appropriately allows for the correlation structure.