Two-Stage Selection and Testing Designs for Comparative Clinical Trials
提出一种两阶段设计，先选出最佳实验治疗再与标准对照比较，允许早期终止并接受全局零假设，通过最小化期望总样本量优化参数。
A two-stage design which selects the best of several experimental treatments and compares it to a standard control is proposed. The design allows early termination with acceptance of the global null hypothesis. Optimal sample size and cut-off parameters are obtained by minimizing expected total sample size for fixed significance level and power.