Generalized Augmentation to Control the False Discovery Exceedance in Multiple Testing
提出一种新的多重检验程序GAUGE,能控制错误发现超额并具有竞争力,可推广至其他错误度量,适用于依赖数据,并在前列腺癌和结肠癌数据上验证。
Abstract. A new multiple testing procedure, the generalized augmentation procedure (GAUGE), is introduced. The procedure is shown to control the false discovery exceedance and to be competitive in terms of power. It is also shown how to apply the idea of GAUGE to achieve control of other error measures. Extensions to dependence are discussed, together with a modification valid under arbitrary dependence. We present an application to an original study on prostate cancer and on a benchmark data set on colon cancer.