Efficient Group Sequential Tests with Unpredictable Group Sizes
提出了一类参数化组序贯检验，能在组大小不等且不可预测时最小化期望样本量，并保持接近名义水平的错误率，适用于需要灵活调整样本量的临床试验或实验设计。
We derive group sequential tests to minimize expected sample size. A parametric family of group sequential tests is proposed containing tests which are nearly optimal, in terms of minimizing expected sample size, amongst all group sequential tests. These parametric tests can be implemented when group sizes are unequal and unpredictable. They are shown to achieve error rates close to their nominal level in a wide range of situations and to be efficient when compared with other tests based on the same group sizes and achieving the same error rates.