Screening by Conference Designs
本文提出一类称为边缘设计的新实验设计，可从会议矩阵构造，能模型无关地估计相关变量，对非线性具有鲁棒性，适用于变量数小于50的筛选实验。
Screening experiments aim to identify the relevant variables within some process potentially depending on a large number of variables. In this paper we introduce a new class of experimental designs called edge designs. These designs allow a model-independent estimate of the set of relevant variables, thus providing more robustness than traditional designs. We give a bound on the determinant of the information matrix of certain edge designs, and show that a large class of edge designs meeting this bound can be constructed from conference matrices. We also show that the resulting conference designs have an optimal space exploration property which guards against unexpected nonlinearities. We survey the existence of and constructions for conference matrices, and, for n < 50 variables, give explicit such matrices when n is a prime, and references to explicit constructions otherwise.