Contrasts for Identifying the Minimum Effective Dose
本文针对剂量反应研究中最小有效剂量的识别问题，提出一种新的对比方法（盆地对比），并通过蒙特卡洛模拟证明其优于现有方法。
Abstract Dose-response studies are frequently used to study the effects of an experimental compound on various responses. One characteristic of the compound that is frequently of interest is the minimum effective dose (MED). Generally, inference about the MED is made by comparing various dose groups with a control (Dunnett 1955; Williams 1971). This article examines two families of contrasts used for related problems, and proposes a new family of contrasts (called basin contrasts) designed specifically for identifying the MED. Monte Carlo studies are used to demonstrate the superiority of the contrast procedures and make recommendations for their use. Key Words: Basin contrastsDunnett's testHelmert contrastsMultiple comparisonsStep contrastsWilliams's test