Optimum Biased Coin Designs for Sequential Clinical Trials with Prognostic factors
利用DA最优实验设计理论，为存在或不存在预后因素的序贯临床试验提供有偏硬币类型的设计，避免了早期方案的许多任意特征。
The theory of DA-optimum design of experiments is used to provide designs of the biased coin type for sequential clinical trials in the presence, or absence, of prognostic factors. The designs avoid many arbitrary features of earlier schemes.