Frequentist Properties of Three Stopping Rules for Comparative Clinical Trials
比较了Begg & Mehta (1979)提出的程序与贝叶斯程序及Anscombe (1963)程序在临床试验中的频率学派性质，发现前者导致过早终止实验，增加分配较差治疗的风险，造成更多患者受到不当治疗。
The frequentist properties of a procedure proposed by Begg & Mehta (1979) for the comparison of two treatments in the context of a clinical trial are compared to those of the Bayes procedure and the procedure proposed by Anscombe (1963). While the last two procedures are quite effective, the first prescribes premature termination of the experimental phase which leads to a greatly increased chance of assigning the inferior treatment to the remaining patients in the clinical trial and results in the mistreatment of an unnecessarily large number of patients.